β-arrestins and G protein-coupled receptor kinases in viral entry: A graphical reviewReview Published on 2023-02-012023-07-11 Journal: Cellular signalling [Category] COVID19(2023년), [키워드] B-arrestin clathrin endocytosis Filovirus flavivirus G protein GPCR GRK Influenza virus Polyomavirus Signaling virus. [DOI] 10.1016/j.cellsig.2022.110558 PMC 바로가기 [Article Type] Review
Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell EntryArticle Published on 2022-12-212023-07-10 Journal: Journal of Virology [Category] COVID19(2023년), [키워드] ACE2 receptor endocytosis SARS-CoV-2 two-pore channel type 2 zebrafish. [DOI] 10.1128/jvi.01418-22 PMC 바로가기
Development of Fluorescence-Tagged SARS-CoV-2 Virus-like Particles by a Tri-Cistronic Vector Expression System for Investigating the Cellular Entry of SARS-CoV-2Article Published on 2022-12-192023-07-11 Journal: Viruses [Category] COVID19(2023년), [키워드] ACE2 cell entry endocytosis fluorescence labeling fusion Rab5 SARS-CoV-2 virus-like particle. [DOI] 10.3390/v14122825 PMC 바로가기
SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Induction of Hypoxic Response in Caco-2 Cells Promote the Expression of Genes Involved in SARS-CoV-2 Endocytosis and TranscytosisArticle Published on 2022-10-012022-11-16 Journal: Doklady. Biochemistry and biophysics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 analyzed Caco-2 Caco-2 cell downregulation elevated endocytosis expression expression level expression of gene hypoxia hypoxic include increase in induction intestine involved LDL LDLR low-density LRP1 LRP4 LRP5 manuscript mechanism miRNA mRNA oxyquinoline receptor response RNA sequencing SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 viral particles significant increase TFRC Transcriptome Transcriptome. transcytosis Transport treated upregulation [DOI] 10.1134/S1607672922050118 PMC 바로가기
Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimabArticle Published on 2022-08-242022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] ACE2 ACE2 binding ACE2 binding site Amino acid angiotensin-converting enzyme 2 antibody Cell cell entry class conserved domain endocytosis Entry epitope escaped Evolution Evolution of SARS-CoV-2 fusion immune Immune escape immunological in vitro infections inhibit SARS-CoV-2 Interaction monoclonal monoclonal antibody not affected pathogenicity plasticity precursor Receptor-binding domain replicated S309 SARS-CoV-2 Sotrovimab. susceptible the spike protein vaccination viral strain wild-type SARS-CoV-2 [DOI] 10.3389/fimmu.2022.966236 PMC 바로가기
Cytoplasmic domain and enzymatic activity of ACE2 are not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cellsSARS-CoV-2의 숙주 세포 내로의 PI4KB 의존성 세포내이입 진입에는 ACE2의 세포질 도메인 및 효소 활성이 필요하지 않습니다Article Published on 2022-06-012022-09-11 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 addition angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin converting enzyme 2 (ACE2) catalytic activity causative agent Cell cellular cellular entry cellular receptor clathrin Clathrin-mediated endocytosis COVID-19 pandemic delta variant demonstrated dependent on domain effective endocytosis entry of SARS-CoV-2 enzymatic activity enzyme health emergency host cell host cells human angiotensin converting enzyme 2 infections intracellular domain lentivirus Phosphoinositides PI4KB predominant principle pseudotype required SARS-CoV-2 Spike protein syncytium syncytium formation Syncytium. treat variant viral entry virus entry [DOI] 10.1016/j.virs.2022.03.003 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infection-Of Music and Mechanics of Its Spikes! A PerspectiveArticle Published on 2022-05-242022-11-15 Journal: ACS Nano [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE2 arising Biochemistry cellular Cobicistat coronavirus COVID-19 COVID-19 pandemic D614G darunavir Disulfide dorian Egmont endocytosis GSH GSSG hydrogen bonds Lipid rafts Lopinavir manifestation Mechanics mechanobiology music Pandemics peptide piezoelectricity produced Remdesivir Research Ritonavir SARS-CoV-2 spikes the SARS-CoV-2 virus Vaccine Vaccines Vaccines. virus virus propagation while [DOI] 10.1021/acsnano.1c11491 PMC 바로가기
The Endolysosomal System: The Acid Test for SARS-CoV-2Review Published on 2022-04-202023-07-02 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, [키워드] acidification autophagy Coronaviruses endocytosis endosome immune evasion Immunity lysosome SARS-CoV-2 virus cycle [DOI] 10.3390/ijms23094576 PMC 바로가기 [Article Type] Review
Role of the renin-angiotensin system in NETosis in the coronavirus disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)의 NETosis에서 레닌-안지오텐신 시스템의 역할Review Published on 2022-04-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACEi angiotensin Angiotensin II angiotensin II type 1 receptor blockers Angiotensin system angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors antagonist ARBs blocker Blood blood pressure Brain cause Complication contribute coronavirus disease COVID-19 death endocytosis Evidence explain Extracellular help hypertension induce Infarction involved kidney Low-density granulocytes lung mechanism Myocardial infarction NET NETosis NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil recruitment Numerous organ Patient patients with COVID-19 procoagulant promote recent recent findings receptor reduce regulate Renin renin-angiotensin system risk role severe COVID-19 stroke thrombosis thrombosis. Treatment Trigger virus [DOI] 10.1016/j.biopha.2022.112718 PMC 바로가기 [Article Type] Review